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How much do you know about creatinine?

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How much do you know about creatinine?

As We know that creatinine is a metabolite by muscle activity.

Normal (for adults) contains creatinine about 100g, of which 98% exist in muscle, update about 2% per day.

Clinically exam of serum creatinine is one of the main methods to know renal function.

So,what is the creatinine?

Endogenous creatinine is a production of human muscle metabolism. In the muscle, creatinine is formed mainly through the irreversible non-enzyme dehydration reaction , released into blood and finally passed out with urine. Therefore, serum creatinine has the close relation with the total amount of musle,not affected by diet. Creatinine is a small molecule material and can be passed through glomerular , rarely absorbed in the renal tubules. Creatinine ,daily produced, almost passes out with urine and is hardly absorbed by renal tubules and not affected by urine volume.

Cells survive by absorbing and consuming nutrients and naturally produce excrement .Creatinine is one of excretions. It should have been excreted out of the kidneys.When the kidneys are ill,the creatinine level will be high.

The normal upper limit of plasma creatinine is about 100 micromoles / liter. And different hospital testing standards are not the same, but not more than 120 micromoles / liter.

When patients have renal insufficiency, creatinine accumulate in the body and the human body toxins. Because of its simple method of operation, less interference factors, high sensitivity, it commonly used as one of the better renal function test clinically.

Article URL : http://www.sjzhospital.com/faq/2446.html

Article by : Shijiazhuang Kidney Disease Hospital

TAG:creatinine,renal function,renal insufficiency

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