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The Formation of Renal Fibrosis

1.Inflammatory cells infiltration

2.Renal inherent cells are damaged, revitalized and secreted. Besides there will be proliferation and apoptosis of cells and transformation of cells’phenotype.

3.Inflammatory factor secretes abnormally.肾脏纤维化.jpg

4. ECM accumulates abnormally.

5.When the function of ECM producing and degradation are imbalanced, a large number of ECM will accumulate and deposit in kidney, which will cause induration of glomerulus and loss of foot cells.

6.Kidney tubules and interstitial capillary blood will decrease, atrophy and can not work. The complete nephrons will decrease gradually until they finally disappear.

7.GFR(glomerulus filtration rate) will drop and ultimately kidneys will lost its function pathologically and physically.

Article URL : http://www.sjzhospital.com/treatment/397.html

Article by : Shijiazhuang Kidney Disease Hospital

TAG:renal fibrosis

Call us: +86311-89261530  Email: june.cao@sjzhospital.com   FACE BOOK The best hospital for renal failure
Address:NO.5 Feiyi Road, Shijiazhuang,Hebei Province.China   Post code:050000 PRIVACY POLICY